DEVELOPMENT AND VALIDATION OF A METHOD FOR TRIAMCINOLONE HEXACETONIDE IN BULK AND DOSAGE FORM BY RP-HPLC

Author(s)	H. Padmalatha
Country	India
Abstract	In the present investigation, a simple, sensitive, precise and accurate Reverse phase high performance liquid Chromatography method developed and validated for estimation of Triamcinolone hexacetonide in injection formulation. This method was simple, since diluted samples are directly used without any preliminary chemical derivatisation or purification steps. Triamcinolone hexacetonide was freely soluble in ethanol, methanol and sparingly soluble in water. ACN: Methanol: water (10:30:60) was chosen as the mobile phase. The solvent system used in this method was economical. The %RSD values were within 2 and the method was found to be precise. The results expressed in tables for RP-HPLC method was promising. The RP-HPLC method is more sensitive, accurate and precise compared to the Spectrophotometric methods. This method can be used for the routine determination of Triamcinolone hexacetonide in injection formulation and in other Pharmaceutical dosage forms.
Keywords	RP-HPLC, Triamcinolone hexacetonide.
Field	Medical / Pharmacy
Published In	Volume 16, Issue 2, July-December 2025
Published On	2025-11-07
Cite This	DEVELOPMENT AND VALIDATION OF A METHOD FOR TRIAMCINOLONE HEXACETONIDE IN BULK AND DOSAGE FORM BY RP-HPLC - H. Padmalatha - IJAIDR Volume 16, Issue 2, July-December 2025.

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