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Validation of RP-HPLC Method for Simultaneous Estimation of Aspirin and Ethoheptazine Citrate in Bulk and Tablet Dosage Form

Author(s) Balakrishnaiah P, Shravani G., Ravindar Bairam, Manjunath SY, Nagi Reddy. N
Country India
Abstract A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Aspirin and ethoheptazine citrate in pharmaceutical dosage form. Chromatographic separation of Aspirin and ethoheptazine citrate was achieved on waters e2695, by using Inertsil -BDS C18 column and the mobile phase containing Acetonitirile and Water in the ratio of 55:45 v/v. The flow rate was 1.0 ml/min and detection was carried out by absorption at 256 nm using a photodiode array detector at ambient temperature .The number of theoretical plates and tailing factor for Aspirin and ethoheptazine citrate were NLT 3000 and RSD NMT 2 respectively. The linearity of the method was excellent over the concentration range 26-104 μg/ml and 6-24 µg/ml for Aspirin and ethoheptazine citrate respectively. The correlation coefficient of Aspirin and ethoheptazine citrate were 0.999 and 0.999. The retention time of Aspirin and ethoheptazine citrate were 2.951 min and 4.195 min respectively. The proposed method was validated according to ICH guidelines. The method was found to be simple , economical , suitable , precise , accurate and robust method for quantitative analysis of Aspirin and ethoheptazine citrate in pure and pharmaceutical dosage form .
Keywords HPLC, Aspirin and Ethoheptazine citrate.
Field Engineering
Published In Volume 16, Issue 2, July-December 2025
Published On 2025-11-25
Cite This Validation of RP-HPLC Method for Simultaneous Estimation of Aspirin and Ethoheptazine Citrate in Bulk and Tablet Dosage Form - Balakrishnaiah P, Shravani G., Ravindar Bairam, Manjunath SY, Nagi Reddy. N - IJAIDR Volume 16, Issue 2, July-December 2025.
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