In silico study of Huperzine B against Alzheimer's Disease

Author(s)	Divyani Vilas Bankar, Syeda Afifa
Country	India
Abstract	Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and neuronal damage. One of the major therapeutic approaches for AD involves inhibiting enzymes associated with disease progression, particularly acetylcholinesterase (AChE), which degrades acetylcholine in the brain. Huperzine B, a naturally occurring alkaloid derived from Huperzia species, has attracted attention due to its neuroprotective and acetylcholinesterase inhibitory properties. Molecular docking studies are widely used to predict the interaction between bioactive compounds and target proteins involved in AD. In this study, molecular docking analysis was performed to evaluate the binding affinity and interaction of Huperzine B with Alzheimer’s disease-related targets, including AChE and other associated enzymes. The docking results demonstrated favorable binding energy and strong interactions between Huperzine B and the active sites of target proteins through hydrogen bonding and hydrophobic interactions.
Field	Chemistry > Pharmacy
Published In	Volume 17, Issue 1, January-June 2026
Published On	2026-05-25
DOI	https://doi.org/10.71097/IJAIDR.v17.i1.1957
Short DOI	https://doi.org/hb5m8d

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