Journal of Advances in Developmental Research

E-ISSN: 0976-4844   •   Impact Factor: 9.71

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 17 Issue 1 January-June 2026 Submit your research before last 3 days of June to publish your research paper in the issue of January-June.
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Volume 17 Issue 1
2026

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Docking study of ellagic acid against SARS COv2 protins

Author(s) Pranali Prakash Borse, Syeda Afifa
Country India
Abstract The global outbreak of COVID-19 caused by the SARS-CoV-2 created an urgent need for effective antiviral agents with improved safety and therapeutic efficacy. In recent years, Computer-Aided Drug Design (CADD) and molecular docking techniques have emerged as important tools in modern drug discovery because they provide rapid, economical, and reliable screening of potential drug candidates. The present study was undertaken to evaluate the antiviral potential of Ellagic Acid, a naturally occurring polyphenolic compound found in pomegranate, berries, and walnuts, against important SARS-CoV-2 proteins through molecular docking analysis. Ellagic acid is known for its antioxidant, anti-inflammatory, and antiviral properties, making it a promising natural therapeutic candidate. In this study, major SARS-CoV-2 target proteins involved in viral replication and infection were selected, including:
• Main Protease (Mpro)
• Spike Glycoprotein
• RNA-Dependent RNA Polymerase (RdRp)
The three-dimensional crystal structures of the selected proteins were retrieved from the Protein Data Bank (PDB) database, while the chemical structure of ellagic acid was obtained from the PubChem Database. Protein and ligand preparation were carried out using standard molecular modeling procedures prior to docking studies. Molecular docking analysis was performed using:
Keywords -
Field Medical / Pharmacy
Published In Volume 17, Issue 1, January-June 2026
Published On 2026-05-25
DOI https://doi.org/10.71097/IJAIDR.v17.i1.1958
Short DOI https://doi.org/hb5m8c
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